Cellular components in aerobic organisms are often confronted with reactive oxygen species (ROS). ROS may damage various biomolecules, such as DNA, proteins, and lipids, and may contribute to the development of cancer, neurodegenerative diseases and other maladies. It also accelerates aging. Sulfur-containing amino acids including methionine are the major targets of ROS and thus the amino acids most susceptible to oxidation. Up-to-date, many enzymes such as Mical and Msr are known to be involved in oxidation and reduction of methionine and methionine sulfoxide, respectively.

   

   Our lab aims to solve mysteries in the regulation of biological functions by utilizing reversible methionine oxidation/reduction by Mical and Msr. We are seeking to understand its underlying mechanism, relevant enzymes, physiological role, and disease association caused by malfunctions. In addition, we are seeking to find a biotechnological application of Msr as a biosensor. This system will be used to monitor real-time oxidative stress change inside cells and detect specific disease conditions. Finally, our lab strives to find the secret of aging by using two model systems, yeast and fruit fly. In particular, we have focused on lifespan extension by methionine restriction and regulation of sulfur metabolism.

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• ​Research Interest

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